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14 April 2015

978 047170 907 7
GBP 119.00

Bioregenerative Engineering: Principles and Applications

Shu Q. Liu

Bioregenerative engineering aims to improve the restoration of the structure and function of not only tissues and organs, but also the cells and even the molecules that lie beneath. One might think that a book which was published on this topic first in 2006 is not worth reading. After all, the field has been moving forward fast and gained the interest of many rapidly over the last years. However, I strongly disagree. I have enjoyed reading this book very much, and would recommend it to scientist and layman alike.

This heavy book (over 1000 pages) consists of two parts comprising three and two subsections respectively. In nine chapters the book covers topics such as regulation of gene expression, important macromolecules, the structure and function of cellular components, cellular signalling and functions, as well as cellular and embryonic development. Each chapter is excellently illustrated by figures, tables and explanatory illustrations.

Part one delivers an in-depth introduction not only to the biological, but also to the engineering aspects of this interesting field and makes it especially easy for newcomers to appreciate this exciting and promising topic. Subsection one (chapters 1 to 4) covers the molecular basics, explaining how macromolecules are organized and genes are regulated. Their influence on the constitution and function of cells and tissues is discussed. Then the order of cellular components and the extracellular matrix are considered from the perspective of their roles in tissue formation. Subsection two (chapters 5 and 6) provides an overview of the regulatory mechanisms of regeneration by covering cell signalling mechanisms and fundamental cell functions. Part one concludes in subsection three (chapters 7 to 9) with an overview on fertilization, embryonic development, the stem cell concept and examples of regenerations mechanisms present in nature. The latter is particularly fascinating on the subject of regeneration of limbs and organs, full of interesting details with explanatory figures. Part one of the book lays the necessary foundation to understand the underlying system through the combination of molecular and regulatory mechanisms of regeneration. This enables the reader to understand the principles and applications of regenerative engineering covered in part two. This introduces the principles of bioengineering, which are further explained in subsection four (chapters 10 to 12). Especially interesting is chapter 12 featuring biomaterials from synthetic polymers to biological materials. Subsection five (chapters 13 to 25) is the most extensive section with an in-depth presentation of the fields of application of regenerative medicine. In 13 chapters bioregenerative engineering is presented from various organ systems, ranging from nerves, vessels, liver, muscle, bone to eyes and skin. The book concludes with a chapter on regenerative engineering in the case of cancer.

This amount of information is almost overwhelming, and the reader quickly realizes how far current medicine and engineering techniques have come and I discovered many interesting new facts. Naturally, one has to understand that this once up-to-date overview of current research is not that up-to-date anymore, and one would need to turn to other more recent sources. However, this book very systematically compiles principles and technologies which are still valid today. Thus, it can be considered a well-compiled guide into the field of bioregenerative/ biomedical engineering suitable for advanced and early scientist as well as physicians. I would personally be very happy if the book were to be updated to the current state of knowledge in a new edition.

Mirja Krause (Technical University of Berlin, Germany)

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